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Index > Protein center > Usp14(Gene name) > Mouse
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  • Usp14 (Gene name),
  • Ubiquitin carboxyl-terminal hydrolase 14 (Protein name ),  UBP14_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Usp14;
    Protein name:
    Ubiquitin carboxyl-terminal hydrolase 14;
    Alternative:
    Ubiquitin thiolesterase 14;Deubiquitinating enzyme 14;Ubiquitin-specific-processing protease 14;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer (Potential). Interacts with FANCC, CXCR4 and ERN1 (By similarity). Associates with the 26S proteasome.
    Function:
    Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Maintains the cellular levels of monomeric ubiquitin in cells. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor cxcr4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1.
    Subcellular Location:
    Cytoplasm Cell membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    493
    Sequence:
    50:
    MPLYSVTVKW | GKEKFEGVEL | NTDEPPMVFK | AQLFALTGVQ | PARQKVMVKG | 
    100:
    GTLKDDDWGN | IKMKNGMTVL | MMGSADALPE | EPSAKTVFVE | DMTEEQLATA | 
    150:
    MELPCGLTNL | GNTCYMNATV | QCIRSVPELK | DALKRYAGAL | RASGEMASAQ | 
    200:
    YITAALRDLF | DSMDKTSSSI | PPIILLQFLH | MAFPQFAEKG | EQGQYLQQDA | 
    250:
    NECWIQMMRV | LQQKLEAIED | DSGRETDSSS | APAVTPSKKK | SLIDQYFGVE | 
    300:
    FETTMKCTES | EEEEVTKGKE | NQLQLSCFIN | QEVKYLFTGL | KLRLQEEITK | 
    350:
    QSPTLQRNAL | YIKSSKISRL | PAYLTIQMVR | FFYKEKESVN | AKVLKDVKFP | 
    400:
    LMLDVYELCT | PELQEKMVSF | RSKFKDLEDK | KVNQQPNAND | KNSPPKEIKY | 
    450:
    EPFSFADDIG | SNNCGYYDLQ | AVLTHQGRSS | SSGHYVSWVR | RKQDEWIKFD | 
    493:
    DDKVSIVTPE | DILRLSGGGD | WHIAYVLLYG | PRRVEIMEEE | SEQ
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    UniGene:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
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    E11578h
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    ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
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    ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
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    ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
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    CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
    Cat.:
    U11578h
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    96T
    CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
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    U11578b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 14
    Cat.:
    U11578m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
    Cat.:
    P11578Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
    Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
    Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
    Cat.:
    P11578Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
    Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
    Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
    Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 14
    Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 14
    Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 14
    Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 14
    Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 14

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    References
    1. 1.
      "Mouse deubiquitinating enzyme-type TGT."
      Hidaka T. , Morishita T.
      Submitted (1999-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Corpora quadrigemina.
      tissue: Embryo.
      tissue: Testis.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14."
      Borodovsky A. , Kessler B.M. , Casagrande R. , Overkleeft H.S. , Wilkinson K.D. , Ploegh H.L.
      EMBO J.20:5187-5196(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION;ASSOCIATION WITH THE 26S PROTEASOME
    5. 5.
      "Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice."
      Anderson C. , Crimmins S. , Wilson J.A. , Korbel G.A. , Ploegh H.L. , Wilson S.M.
      J. Neurochem.95:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ASSOCIATION WITH THE 26S PROTEASOME
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    7. 7.
      "The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions."
      Chen P.C. , Qin L.N. , Li X.M. , Walters B.J. , Wilson J.A. , Mei L. , Wilson S.M.
      J. Neurosci.29:10909-10919(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Solution structure of the N-terminal ubiquitin-like domain of mouse ubiquitin specific protease 14 (usp14)."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2004-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 4-86
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